C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/34 (2006.01) A61K 31/437 (2006.01) A61K 31/52 (2006.01) A61P 3/10 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2376835
The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I) (see formula I) (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
La présente invention concerne de nouveaux composés imidazole fusionnés représentés par la formule générale (I), certains de leurs sels, hydrates ou ensemble des deux, pharmacologiquement acceptables. Ces composés, qui font preuve d'antagonisme pour le récepteur A2 de l'adénosine, sont indiqués pour la prévention et le traitement du diabète sucré et des complications des diabètes. Dans cette formule, R<1> est amino éventuellement alkylé ou analogue, R<2> est hydrogène, alkyle ou analogue, R<3> est un aryle éventuellement substitué, un groupe pyridinone, un groupe pyrimidinone ou analogue, Ar est un groupe aryle ou hétéroaryle éventuellement substitué, ou analogue, et A et W sont chacun indépendamment N ou CH.
Akamatsu Hiroshi
Asano Osamu
Haga Toyokazu
Harada Hitoshi
Hayashi Kenji
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Smart & Biggar
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