C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/273
C07D 471/04 (2006.01) A61K 31/395 (2006.01) C07D 403/10 (2006.01) C07D 473/00 (2006.01) C07D 473/40 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2028880
ABSTRACT There are described compounds of the formula: Image wherein R1 is lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl or lower alkylthio, R2 is hydrogen or imino-protective group, R3 is hydrogen or halogen, A is lower alkylene, and Image is a group of the formula : Image , Image or Image in which X1, X2, X3 and X4 are each N or CR4, in which R4 is hydrogen, lower alkyl, lower alkoxy, halogen, halo(lower)alkyl, esterified carboxy, halo(lower)alkoxy or hydroxy, provided that at least one of X1, X2, X3 and X4 is N, and pharmaceutically acceptable salts thereof. These compounds are useful as potent and selective antagonists of angiotensin II receptor and can be used as therapeutical and/or preventive agents for cardiopathy (e.g. angina pectoris, arrhythmia, miocardial infarction, etc.) hyperaldosteronism cerebral vascular diseases, senile dementia, ophthalmic diseases (e.g.) glaucoma, etc.), and the like, as well as diagnostic agents for testing the renin angiotensin system. The preparation of these compounds , pharmaceutical compositions containing them, the medical treatment or prevention of angiotensin II mediated diseases, hypertension or heart failure using these compounds are also disclosed.
Hashimoto Masashi
Inoue Takayuki
Katayama Akira
Kayakiri Hiroshi
Kuroda Akio
Fujisawa Pharmaceutical Co. Ltd.
Hashimoto Masashi
Inoue Takayuki
Katayama Akira
Kayakiri Hiroshi
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