Condensed imidazolo derivatives for the inhibition of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/50 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2619660

The present invention provides a compound of formula (I): Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

Cette invention concerne un composé représenté par la formule (I). Ce composé est un inhibiteur de l'aldostérone synthase et de l'aromatase et peut par conséquent être utilisé dans le traitement d'un trouble ou d'une maladie induit par l'aldostérone synthase ou l'aromatase. Ainsi, le composé représenté par la formule (I) peut être utilisé pour traiter l'hypokaliémie, l'hypertension, l'insuffisance cardiaque congestive, la fibrillation auriculaire, l'insuffisance rénale, en particulier l'insuffisance rénale chronique, la resténose, l'athérosclérose, le syndrome X, l'obésité, la néphropathie, le post-infarctus myocardique, les coronaropathies, l'inflammation, la surproduction de collagène, la fibrose telle que la fibrose cardiaque ou myocardique et le remodelage suite à une hypertension et à un dysfonctionnement endothélial, la gynécomastie, l'ostéoporose, le cancer de la prostate, l'endométriose, les fibroïdes utérins, la ménométrorragie, l'hyperplasie endométriale, la maladie des ovaires polykystiques, l'infertilité, la maladie mammaire fibrokystique, le cancer du sein et la mastopathie fibrokystique. Cette invention concerne enfin une composition pharmaceutique.

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