C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/238
C07D 231/54 (2006.01) A61K 31/415 (2006.01) C07D 491/052 (2006.01) C07D 491/06 (2006.01) C07D 495/06 (2006.01)
Patent
CA 1310648
A B S T R A C T Condensed pyrazole derivatives and process for their preparation. The invention relates to compounds having the general formula (I) (I) Image wherein Z represents a C2-C6 alkylene chain or a -CH=CH-CH= group or an -E-CHR4-(CH2)p- group, in which p is zero, 1 or 2; E represents an oxygen atom or a ?S(O)q group, wherein q is zero, 1 or 2; and R4 is hydrogen or C1-C3 alkyl; R1 represents C1-C6 alkyl, benzyl, pyridyl or phenyl, the phenyl being unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoro- methyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, formyl- amino and C2-C8 alkanoylamino; each of R2 and R3 is independently: Abstract a) hydrogen, halogen or C1-C6 alkyl; b) hydroxy, C1-C6 alkoxy or C3-C4 alkenyloxy; or c) nitro, amino, formylamino or C2-C3 alkanoylamino; and W represents: a') a -CO-?H-S(O)n-CH3 group, wherein n is 1 or 2 and R represents hydrogen or C1-C6 alkyl; or b') a -CO-?H-CN group, wherein Q represents hydrogen, carb- oxy, CONH2, C2-C7 alkoxycarbonyl or a Image or a Image group, wherein Ra represents hydrogen or C1-C20 alkyl and Rb represents C1-C20 alkyl or a -(CH2)m-R5 group, wherein m is zero, 1 or 2 and R5 is: a") C5-C8 cycloalkyl; b") pyridyl unsubstituted or substituted by one or two substituents chosen independently from halogen, C1-C6 alkyl and C1-C6 alkoxy; or c") phenyl unsubstituted or substituted by one or two substituents independently chosen from halogen, CF3, C1-C6 alkyl, C1-C6 alkoxy, amino, nitro, formylamino, C2-C8 alkanoylamino, di(C1-C6 alkyl)amino, hydroxy, formyloxy and C2-C8 alkanoyloxy, and the pharmaceu- tically acceptable salts thereof, which possess immunomodu- lating activity and are useful e.g. in the treatment of neo- plastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.
556898
Doria Gianfederico
Ferrari Mario
Isetta Anna M.
Trizio Domenico
Doria Gianfederico
Farmitalia Carlo Erba S.p.a.
Ferrari Mario
Fetherstonhaugh & Co.
Isetta Anna M.
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