Condensed pyridazine compounds, their production and use

Details Condensed pyridazine compounds, their production and use Condensed pyridazine compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2346659

Compounds represented by general formula (I), salts of the same, or prodrugs of both, which exhibit antiallergic, antihistaminic, eosinotaxis-inhibitory, anti-inflammatory and anti-PAF effects, and so on, and are therefore useful as preventive and therapeutic agents for asthma or the like, wherein A is a ring represented by general formula (a) or (b) (wherein R1a and R1b are each hydrogen or the like); Ar1 and Ar2 are each an optionally substituted aromatic group, or alternatively Ar1 and Ar2 together with the carbon atom adjacent to them may form a fused ring; B is a piperidine ring, a piperazine ring, or the like; X and Y are each oxygen, a divalent linear lower hydrocarbon group which may be interrupted by one to three heteroatoms, or the like; R2 and R3 are each hydrogen or the like; and R7 is hydrogen or the like.

L'invention concerne des composés représentés par la formule générale (I), des sels de ces composés, ou des promédicaments de ces composés ou sels présentant des effets antiallergiques, antihistaminiques, inhibiteurs d'éosinotaxis, anti-inflammatoires et anti-PAF, etc, et utilisés en conséquence comme agents préventifs et thérapeutiques pour l'asthme ou analogue, formule dans laquelle A désigne un noyau représenté par la formule générale (a) ou (b) (où R?1a¿ et R?1b¿ désignent chacun un hydrogène ou analogue); Ar?1¿ et Ar?2¿ désignent chacun un groupe aromatique éventuellement substitué, ou, en variante, Ar?1¿ et Ar?2¿ forment, conjointement avec l'atome de carbone qui leur est adjacent, un noyau condensé; B désigne un noyau pipéridine, un noyau pipérazine ou analogue; X et Y désignent chacun un oxygène, un groupe hydrocarbure inférieur linéaire divalent pouvant être interrompu par un à trois hétéroatomes, ou analogue; R?2¿ et R?3¿ désignent chacun un hydrogène ou analogue, et R?7¿, un hydrogène ou analogue.

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