Condensed pyridazine derivatives, their production and use

Details Condensed pyridazine derivatives, their production and use Condensed pyridazine derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2348022

Compounds represented by general formula (I), salts of the same, or prodrugs of both, which exhibit excellent, antiallergic, antihistaminic, anti- inflammatory and eosinotaxis-inhibitory effects, and so on, and are therefore useful as preventive and therapeutic agents for allergic dermatosis wherein Ar1 and Ar2 are each an optionally substituted aromatic group, or alternatively Ar1 and Ar2 together with the carbon atom adjacent to them may form a fused ring; B is a piperidine ring, a piperazine ring, or the like; X and Y are each oxygen, a divalent linear lower hydrocarbon group which may be interrupted by one to three heteroatoms, or the like; A is nitrogen or CR7 (wherein R7 is hydrogen or the like); R1, R2 and R3 are each hydrogen or the like; and R8 is hydrogen or the like.

L'invention concerne des composés correspondant à la formule générale (I), leurs sels ou des promédicaments préparés à partir de ces composés ou sels; ces promédicaments manifestent d'excellents effets hypoallergiques, antihistaminiques, anti-inflammatoires, possèdent une action inhibitrice sur les oesinotaxes, etc. Ces sels et composés peuvent servir d'agents pour prévenir ou traiter la dermatose allergique. Dans la formule (I), Ar?1¿ et Ar?2¿ sont chacun un groupe aromatique substitué en option; ils peuvent éventuellement former, conjointement avec l'atome de carbone adjacent, un noyau fusionné. B est un noyau pipéridine, pipérazine ou similaire; X et Y sont chacun oxygène, un groupe bivalent d'hydrocarbures linéaires inférieurs qui peut être interrompu par des hétéroatomes dont le nombre est compris entre un et trois, ou similaire; A est azote ou CR?7¿ (R?7¿ étant hydrogène ou similaire); R?1¿, R?2¿ et R?3¿ sont chacun hydrogène ou similaire; et R?8¿ est hydrogène ou similaire.

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