Condensed pyridine derivatives useful as a28 adenosine...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4427 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 213/73 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2562369

The present invention relates to new antagonists of the A2B adenosine receptor represented by formula (I). Those compounds are useful for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor such as asthma, bronchoconstriction, allergic diseases, hypertension, atherosclerosis, reperfusion injury, myocardial ischemia, retinopathy, inflammation, gastrointestinal tract disorders, cell proliferation disorders, diabetes mellitus, and/or autoimmune diseases.

L'invention concerne des antagonistes du récepteur de l'adénosine A2B représentés par la formule (I). Ces composés sont utiles dans le traitement d'un sujet souffrant d'un état ou d'une maladie pathologique pouvant être amélioré par antagonisme du récepteur de l'adénosine A2B, tel que l'asthme, la bronchoconstriction, des maladies allergiques, l'hypertension, l'athérosclérose, une lésion de reperfusion, l'ischémie myocardique, la rétinopathie, des inflammations, des troubles du tractus gastro-intestinal, des troubles de la prolifération cellulaire, le diabète sucré et/ou des maladies auto-immunes.

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