Condensed pyridoindole derivatives

Details Condensed pyridoindole derivatives Condensed pyridoindole derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 15/10 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 249/00 (2006.01)

Patent

CA 2423308

Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. In particular, the invention relates to compounds that, are potent and selective inhibitors of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP- specific PDE), in particular PDE5, ad have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.

Cette invention, qui a trait à des composés correspondant à la formule générale de structure (I), concerne également l'utilisation de ces composés, de leurs sels et de leurs solvates en tant qu'agents thérapeutiques.

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