Condensed pyrimidine derivatives, their production and use

Details Condensed pyrimidine derivatives, their production and use Condensed pyrimidine derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2085950

Condensed Pyrimidine Derivatives, Their Production and Use Abstract Novel compounds of the general formula: Image wherein a ring A represents a pyrrole or pyrroline ring which may be substituted; B means a divalent 5- or 6- membered homo- or hetero-cyclic group which may be substituted; Y means a hydrogen atom, a halogen atom, or a group bonded through a carbon, nitrogen or sulfur atom; R1 and R2 each means a hydrogen atom or a lower hydrocarbon group which may be substituted; -COOR3 and -COOR4 each means a carboxyl group which may be esterified; n means a whole number of 1 through 6, or a salt thereof, possessing of surprisingly high inhibitory activity against thymidylate synthase, and their production and use.

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