C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/300, 260/321
C07D 209/46 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07F 9/553 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01)
Patent
CA 1196330
Abstract of the Disclosure The compound of the formula Image wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is -CH=CH-CH=CH-, -S-(CH2)?-S- (? is an integer of 1 to 3), -N=CH-CH=N- or -(CH2)m- (m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong anti- anxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis. The compounds are produced by (a) reacting a compound of the formula Image with a compound of formula Ph3 P=CHY, (b) decarboxylating a corresponding malonate, (c) hydrolyzing a corresponding nitrile, and if necessary, hydrolyzing, esterifying or amidating.
424994
Hiraga Kentaro
Saji Yoshiaki
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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