Condensed ring compound and use thereof

Details Condensed ring compound and use thereof Condensed ring compound and use thereof

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/538 (2006.01) A61K 45/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 43/00 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2537355

Compound of the general formula: (I) (wherein all the symbols have the same meaning as in the description). This compound exhibits antagonism against cysLT2 receptor, so that it is useful as, for example, a preventive and/or therapeutic agent for respiratory diseases (for example, bronchial asthma, chronic obstructive lung disease, pulmonary emphysema, chronic bronchitis, pneumonia (e.g., interstitial myositis, etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g., acute sinusitis, chronic sinusitis, etc.), etc.), or as an expectorant agent or cough suppressant.

L'invention concerne un composé représenté par la formule générale (I), dans laquelle tous les symboles sont tels que définis dans le descriptif. Ce composé présente une activité antagoniste contre le récepteur de cysLT¿2?, de sorte qu'il est utile, par exemple, en tant qu'agent prophylactique et/ou thérapeutique pour des maladies respiratoires telles que l'asthme, la maladie respiratoire chronique, l'emphysème pulmonaire, la bronchite chronique, la pneumonie (notamment la myosite interstitielle), le syndrome respiratoire aigu sévère (SARS), le syndrome de détresse respiratoire aigu (ARDS), la rhinite allergique, la sinusite (notamment la sinusite aiguë, chronique), etc. ou en tant qu'expectorant ou antitussif.

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