Condensed thiazole compounds, their production and use

C - Chemistry – Metallurgy – 07 – D

Patent

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167/231, 167/234

C07D 513/04 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) C07D 211/76 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2036905

A novel condensed thiazole derivative of the formula (I): (see formula I) wherein A is a single bond or CH2; R1 is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulfonic aryl group; and R2 is hydrogen atom, or an optionally substituted aromatic cyclic or aliphatic group or a salt thereof. The compound [I] is useful for medicines for preventing and treating various diseases such as cancer, arterial sclerosis, hepatopathy, cerebrovascular diseases, inflammatory and the like. A process of the compound of the formula (I) or a salt thereof and a pharmaceutical composition comprising the compound of the formula (I) or a pharmaceutically acceptable salt thereof as an active component are also disclosed.

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