Condensed thiophene compound and pharmaceutical use thereof

Details Condensed thiophene compound and pharmaceutical use thereof Condensed thiophene compound and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2104371

Abstract A condensed thiophene compound represented by general formula: Image ( I ) or a pharmaceutically acceptable salt thereof, wherein ring S represents a thiophene ring; R1 represents hydrogen, halogen, alkyl, etc.; R2 represents hydrogen, alkyl, acyl, etc.; G represents -CH2-, -CH(OH)-, -CO-, etc.; Q represents alkylene; T represents -NH2, -NHRa (wherein Ra represents alkyl, cycloalkyl, etc.) or -N(Rb)(Rc) (wherein Rb, Rc represents each alkyl etc.; or alternatively Rb and Rc are combined together to form cyclic amino); D represents -CH2- or -S-; A and B represent each carbonyl or thiocarbonyl, or are null; and m and n represent each 0, 1 to 4, provided that m+n represents an integer of 4 or less. This compound is useful as an antipsychotic drug having a reduced extrapyramidal side effect or an antianxiety drug. 149

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