Condensed thiophene compounds and pharmaceutical use thereof

Details Condensed thiophene compounds and pharmaceutical use thereof Condensed thiophene compounds and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/55 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2302409

Fused thiophene compounds represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein each symbol is as defined in the description. The compounds of general formula (I) are useful as novel antipsychotics which are efficacious against both of positive and negative symptoms of schizophrenia, exhibit little side effects such as extrapyramidal motility disturbance, and have little severe side effects such as granulocytopenia. These compounds are also useful as remedies for dementia of Alzheimer type and periodic psychosis.

L'invention concerne des composés thiophène condensés correspondant à la formule générale (I), ainsi que des sels ou hydrates de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule chaque symbole possède les notations données dans la description. Ces composés de la formule (I) sont utiles en tant que nouveaux neuroleptiques et sont efficaces à la fois contre des symptômes positifs et négatifs de la schizophrénie, possèdent peu d'effets secondaires, comme les troubles du système moteur extrapyramidal, et peu d'effets secondaires graves comme la granulocytopénie. Ces composés sont également utiles en tant que médicaments destinés à la démence du type Alzheimer et aux psychoses cyclothymiques.

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