C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/4196 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2570319
The present invention relates to triazolopyrimidines, imidazolopyrimidines and derivatives thereof of Formula (I), and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ~ cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shack syndrome, fever, myalgias due to HIV-l, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
La présente invention concerne des triazolopyrimidines, des imidazolopyrimidines et leurs dérivés de formule (I), ainsi que des sels pharmaceutiquement acceptables de ces composés. Est également décrite une méthode de traitement, par administration d'une dose efficace d'un composé susdécrit, des affections et troubles suivants survenus chez un mammifère: inflammation, polyarthrite rhumatoïde, maladie de Page, ostéoporose, myélome multiple, uvéite, leucémie myéloïde aiguë ou chronique, destruction des cellules ß du pancréas, arthrose, spondylarthrite ankylosante, arthrite goutteuse, maladie intestinale inflammatoire, syndrome de détresse respiratoire aiguë (SDRA), psoriasis, maladie de Crohn, rhinite allergique, colite ulcéreuse, anaphylaxie, dermite de contact, asthme, dégénérescence musculaire, cachexie, syndrome oculo-urétrosynovial, diabète de type I, diabète de type II, maladies à résorption osseuse, rejet de greffe, maladie d'Alzheimer, attaque cardiaque, infarctus du myocarde, lésions d'ischémie/reperfusion, athérosclérose, accident cérébral, sclérose en plaques, accès pernicieux, sepsis, choc septique, syndrome de choc toxique, fièvre, myalgies dues au VIH-1, VIH-2 VIH3, cytomégalovirus (CMV), grippe, adénovirus, infection due à des virus herpétiques ou zona.
Andersen Denise Lyn
Frohn Michael J.
Hong Fang-Tsao
Liu Longbin
Lopez Patricia
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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