Conditional expression system

Details Conditional expression system Conditional expression system

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/70 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2214451

The present invention relates to a new conditional gene expression system. The system is based on the creation and expression of bispecific chimeric molecules comprising a domain capable of selectively binding a defined DNA sequence and a detector domain capable of specifically binding a transactivator or transrepressor or a transactivator or transrepressor complex.

La présente invention concerne un nouveau système conditionnel pour l'expression de gènes. Le système de l'invention est basé notamment sur la création et l'expression de molécules chimériques bispécifiques comprenant un domaine capable de lier sélectivement une séquence définie d'ADN et un domaine détecteur capable de lier spécifiquement un transactivateur ou transrépresseur ou un complexe transactivateur ou transrépresseur.

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