C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A01K 67/027 (2006.01) C12N 15/90 (2006.01)
Patent
CA 2387737
The present invention relates to a gene trapping construct which causes conditional mutations in genes, and the use of this gene trapping construct to mutationally inactivate all cellular genes. In addition the invention relates to a cell, preferably a mammalian cell which contains the above mentioned construct. Moreover, the invention relates to the use of said cell for identification and/or isolation of genes and for the creation of transgenic organisms to study gene function at various developmental stages, including the adult. In conclusion, the present invention provides a process which enables a temporally and/or spatially restricted inactivation of all genes that constitute a living organism.
La présente invention concerne une construction de piégeage de gènes provoquant des mutations conditionnelles dans des gènes, et l'utilisation de cette construction de piégeage de gènes pour l'inactivation de tous les gènes cellulaires de manière mutationnelle. L'invention concerne en outre une cellule, de préférence une cellule mammifère comportant ladite construction. L'invention concerne également l'utilisation de ladite cellule pour l'isolation et/ou l'identification de gènes, et pour la création d'organismes transgéniques en vue d'étudier les fonctions génétiques à différentes étapes du développement, y compris à l'âge adulte. L'invention concerne enfin un procédé permettant une inactivation restreinte temporelle et/ou spatiale de tous les gènes constituant un organisme vivant.
Altschmied Joachim
Kuhn Ralf
von Melchener Harald
Artemis Pharmaceuticals Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Frankgen Biotechnologie Ag
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