Conditional immortalisation of cells

Details Conditional immortalisation of cells Conditional immortalisation of cells

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 35/30 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2383253

A recombinant, or genetically engineered, mammalian cell, comprises a conditionally-inducible oncogene and an exogenous polynucleotide encoding the catalytic sub-unit of the telomerase complex. The recombinant cells are useful in therapy, to replace lost or damaged cells.

L'invention concerne une cellule mammalienne de recombinaison, ou issue du génie génétique, qui comprend un oncogène pouvant être induit de façon conditionnelle et un polynucléotide exogène codant la sous-unité catalytique du complexe télomérase. Ce type de cellule de recombinaison est utile en thérapie, pour remplacer les cellules perdues ou endommagées.

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