Conditionally-immortalised pancreatic cells

Details Conditionally-immortalised pancreatic cells Conditionally-immortalised pancreatic cells

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2628408

Conditionally immortalized pancreatic cells are produced which remain immortal in the presence of 4-hydroxytamoxifen (4-OHT) but express normal pancreatic cell markers when 4-OHT is not present. The cells therefore permit cell lines to be constructed to produce cells useful for transplantation or in screening assays.

La présente invention concerne la production de cellules pancréatiques immortalisées de façon conditionnelle qui demeurent immortelles en présence de 4-hydroxytamoxifène (4-OHT) mais qui expriment des marqueurs des cellules pancréatiques normales en l'absence de 4-OHT. Les cellules permettent par conséquent la construction de lignées cellulaires afin de produire des cellules pouvant être utilisées pour une greffe ou dans des essais de criblage.

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