C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/074 (2010.01) C12N 5/0735 (2010.01) A01K 67/027 (2006.01) A01N 63/00 (2006.01) A61K 35/12 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C07K 14/82 (2006.01)
Patent
CA 2626525
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
L'invention concerne des procédés d'immortalisation conditionnelle de cellules souches, notamment de cellules souches adultes et embryonnaires, les cellules produites au moyen de ces procédés, des procédés thérapeutiques, des procédés de laboratoire ou des procédés de recherche faisant intervenir ces cellules, et des procédés d'identification de composés liés à la différentiation et au développement cellulaire ou des procédés de traitement de maladies au moyen de ces cellules. L'invention concerne également un modèle de souris de la leucémie myéloïde aiguë (AML) et des procédés associés à un tel modèle de souris.
Cambier John
Johnson Sara Ann
Refaeli Yosef
Turner Brian Curtis
Gowling Lafleur Henderson Llp
National Jewish Health
National Jewish Medical And Research Center
The Regents Of The University Of Colorado
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