C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2627638
The present invention provides for methods and compositions for translation of a viral vector both in vitro and in vivo. Specifically, the present invention pertains to a transnational control element placed in a vector to a cause a selective translation of a viral vector. In one embodiment, the present invention provides for methods and compositions for conditionally expressing a viral vector inside tumor cells, while leaving normal cells unaffected due to their inability to translate the vector.
La présente invention concerne des méthodes et des compositions pour la traduction d'un vecteur viral in vitro et in vivo. Spécifiquement, la présente invention concerne un élément de commande traductionnel placé dans un vecteur pour causer une traduction sélective d'un vecteur viral. Dans un mode de réalisation, la présente invention prévoit des méthodes et des compositions pour exprimer de façon conditionnelle un vecteur viral à l'intérieur de cellules tumorales, sans affecter les cellules normales du fait de leur incapacité à traduire le vecteur.
Curiel David T.
Debenedetti Arrigo
Mathis Michael James
Curiel David T.
Debenedetti Arrigo
Macpherson Leslie & Tyerman Llp
Mathis Michael James
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