Conductivity-normalized urinary analyte concentration...

G - Physics – 01 – N

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G01N 33/493 (2006.01) G01N 33/88 (2006.01)

Patent

CA 2416065

The invention relates to a method for the diagnosis of a medical condition in a subject, comprising the steps of measuring the concentration of one or more analytes, relevant for the diagnosis of said medical condition, in a urine sample; measuring the electrical conductivity of said urine sample; obtaining a normalized value for the analyte concentration by dividing said analyte concentration by the electrical conductivity; and determining whether said subject is suffering from said medical condition by means of comparing the normalized value with a pre-determined reference value. The medical condition to be diagnosed can be, for example, an acute cardiac condition for which the relevant urinary analyte can be one or more thromboxanes.

L'invention concerne une méthode permettant le diagnostic d'un état pathologique chez un sujet. Cette méthode comprend les étapes suivantes : on mesure la concentration dans un échantillon d'urine d'un ou de plusieurs analytes déterminants pour le diagnostic de la pathologie en question, on mesure la conductivité électrique de cet échantillon d'urine, on calcule une valeur normalisée de la concentration d'analyte en divisant cette concentration par la conductivité électrique, et on détermine si le sujet présente un état pathologique en comparant cette valeur normalisée à une valeur de référence prédéterminée. Les pathologies pouvant être diagnostiquées comprennent par exemple les cardiopathies aiguës pour lesquelles l'analyte urinaire correspondant peut être une ou plusieurs thromboxanes.

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