C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457789
The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.
La présente invention facilite l'évaluation in silico de molécules dans une activité biologique au moyen d'un procédé informatisé de façon à prédire si les oligonucléotides peuvent avoir une activité biologique et à déterminer l'efficacité de l'activité biologique sur la base de la structure tridimensionnelle et des caractéristiques des charges des oligonucléotides. Les activités biologiques sont, mais pas exclusivement, la prolifération cellulaire, l'induction de l'arrêt du cycle cellulaire et de l'apoptose.
Filion Mario C.
Holan Zdenek Richard
Phillips Nigel C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Bioniche Life Sciences Inc.
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