Conformation-specific anti-von willebrand factor antibodies

Details Conformation-specific anti-von willebrand factor antibodies Conformation-specific anti-von willebrand factor antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/36 (2006.01) A61K 38/36 (2006.01) A61K 39/395 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2344606

The present invention is directed to antibodies and antibody fragments that bind specifically to the active conformation of human Von Willebrand factor. Most preferred are recombinantly produced single chain variable immunoglobulin fragments. Because the antibodies or antibody fragments act only at the sites of thrombus formation and do not interfere with the normal activity of circulating platelets, they are particularly well suited for use as antithrombotic agents in a wide variety of applications.

L'invention concerne des anticorps et des fragments d'anticorps qui se fixent spécifiquement sur la conformation active du facteur de Von Willebrand humain. Les anticorps préférés sont des fragments constitués de la région variable à chaîne unique des immunoglobulines, produits par recombinaison. Du fait que lesdits anticorps ou fragments d'anticorps n'agissent qu'au niveau des sites de formation du thrombus et n'interfèrent pas avec l'activité normale des plaquettes circulantes, ils conviennent particulièrement bien comme antithrombotiques dans une large gamme d'applications.

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