Conformation specific antibodies

Details Conformation specific antibodies Conformation specific antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 49/06 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2554965

The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (~aLFA- 1~), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.

Cette invention concerne notamment des protéines de liaison (telles que des anticorps) qui se lient à une intégrine dans une conformation activée, telle qu'une LFA-1 activée ("aLFA-1"), par exemple par rapport à une conformation non activée de LFA-1. Dans un mode de réalisation, les protéines de liaison inhibent au moins une fonction d'une aLFA-1, telle qu'une interaction de liaison entre une aLFA-1 et un ligand parent d'une aLFA-1, tel qu'une protéine ICAM. Les protéines de liaison peuvent être utilisées pour traiter ou prévenir un trouble inflammatoire ou autre.

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