Conformationally constrained backbone cyclized interleukin-6...

Details Conformationally constrained backbone cyclized interleukin-6... Conformationally constrained backbone cyclized interleukin-6...

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 7/50 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2375657

Novel peptides which are conformationally constrained backbone cyclized antagonists of IL-6, are disclosed. Methods for synthesizing the IL-6 antagonists are also disclosed. Furthermore, pharmaceutical compositions comprising IL-6 antagonists, and methods of using such compositions are disclosed.

La présente invention concerne de nouveaux peptides qui sont des antagonistes cyclisés d'interleukine-6 à squelette contrainte par conformation. L'invention concerne également des procédés de synthèse d'antagonistes d'IL-6. L'invention concerne en outre des compositions pharmaceutiques comprenant des antagonistes d'IL-6, et des procédés d'utilisation desdites compositions.

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