Conformationally constrained backbone cyclized somatostatin...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/655 (2006.01) A61K 38/12 (2006.01) A61K 38/31 (2006.01) C07K 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262778

Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions in the treatment of endocrine disorders, neoplasms and metabolic disorders are also disclosed.

L'invention concerne de nouveaux analogues peptidiques. Ces nouveaux peptides sont des analogues de la somatostatine cyclisés par squelette à contrainte de conformation. Des procédés de synthèse des analogues de la somatostatine et de production de banques d'analogues de la somatostatine sont également décrits, ainsi que des compositions pharmaceutiques comprenant ces analogues, des procédés d'utilisation de ces compositions dans le traitement de troubles endocriniens, des néoplasmes et des troubles métaboliques.

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