Conformationally constrained smac mimetics and the uses thereof

Details Conformationally constrained smac mimetics and the uses thereof Conformationally constrained smac mimetics and the uses thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07D 515/04 (2006.01)

Patent

CA 2553874

The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

L'invention concerne des mimétiques de smac contraints de manière conformationnelle utilisés en tant qu'inhibiteurs de protéines inhibitrices de l'apoptose. L'invention concerne également l'utilisation de ces mimétiques pour induire la mort cellulaire apoptotique et pour sensibiliser des cellules à des inducteurs de l'apoptose.

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