Conformationally-restricted combinatorial library...

Details Conformationally-restricted combinatorial library... Conformationally-restricted combinatorial library...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 7/00 (2006.01)

Patent

CA 2361012

Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized, alpha-helical polypeptides having a similar tertiary structure but different amino acid residues at specific, "variable" positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.

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