Conformationally stabilized cell adhesion peptides

Details Conformationally stabilized cell adhesion peptides Conformationally stabilized cell adhesion peptides

C - Chemistry, Metallurgy

07

K

167/326, 530/7.0

C07K 14/435 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61L 27/00 (2006.01) C07K 1/00 (2006.01) C07K 4/12 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341106

Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

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