C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 31/4015 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61P 25/28 (2006.01) C07K 5/083 (2006.01) C12P 11/00 (2006.01) C12P 13/00 (2006.01) C12P 13/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2461033
The invention relates to compounds of formula (I), which are formed from the micro-organism Coniochaeta ellipsoidea Udagawa, DSM 13856, or from one of its mutations and/or variants during fermentation and which optionally are chemically converted into derivatives. The invention also relates to a method for producing compounds of formula (I) and to the use of the same as medicaments. In addition, the invention relates to the use of a compound of formula (VI) for producing a medicament for the treatment and prophylaxis of degenerative neuropathies or Alzheimer's disease.
L'invention concerne des composés de formule (I), formés pendant la fermentation par le micro-organisme Coniochaeta ellipsoidea Udagawa, DSM 13856, ou par un de ses mutants et/ou variantes, ou éventuellement transformés chimiquement en dérivés de ceux-ci. La présente invention porte également sur un procédé pour produire des composés de formule (I) et sur leur utilisation comme médicament. En outre, l'invention concerne l'utilisation d'un composé de formule (VI) pour réaliser un médicament destiné au traitement thérapeutique ou prophylactique de neuropathies dégénératives ou de la maladie d'Alzheimer.
Ehrlich Klaus
Kurz Michael
Segeth Marian Paul
Toti Luigi
Vertesy Laszlo
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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