Conjugate based systems for controlled drug delivery

Details Conjugate based systems for controlled drug delivery Conjugate based systems for controlled drug delivery

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2750262

Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.

L'invention concerne des conjugués qui comprennent un médicamentset un ligand qui comprend un premier saccharide. Le conjugué est caractérisé en ce que, lorsqu'il est administré à un mammifère, au moins une propriété pharmacocinétique ou pharmacodynamique de celui-ci est sensible à la concentration de sérum d'un second saccharide. Outre des procédés d'utilisation et de préparation de ces conjugués, l'invention concerne également des exemples de conjugués et des formulations à libération prolongée.

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