A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 257/02 (2006.01) C07F 9/6524 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2058985
2058985 9116078 PCTABS00007 Conjugate compounds are described comprising a compound of formula (1), wherein A is a group -Alk3- or -Alk3N(R4)Alk4-; Alk1, Alk2, Alk3 and Alk4 which may be the same or different is each a C1-4alkylene chain optionally substituted by one or more C1-6alkyl groups; and R1, R2, R3 and R4, which may be the same or different, is each a hydrogen atom or a group-AlkR5 where Alk is an optionally substituted straight or branched C1-6 alkyl group and R5 is a hydrogen atom or a -CO2H, -CONR6R7 (where R6 and R7, which may be the same or different is each a hydrogen atom or an alkyl group) or -P(X1)(X2R8)L group where X1 and X2 is each an oxygen or sulphur atom, R8 is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R1, R2, R3 and R4 is a group AlkP(X1)(X2R8)L where L is a linker group; and a metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.
Beeley Nigel Robert Arnold
Millican Thomas Andrew
Parker David
Celltech Therapeutics Limited
Kirby Eades Gale Baker
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