Conjugate heat shock protein-binding peptides

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2308299

The present invention relates (i) to conjugate peptides engineered to noncovalently bind to heat shock proteins; (ii) to compositions comprising such conjugate peptides, optionally bound to heat shock protein; and (iii) to methods of using such compositions to induce an immune response in a subject in need of such treatment. It is based, at least in part, on the discovery of tethering molecules which may be used to non-covalently link antigenic peptides to heat shock proteins. The present invention also provides for methods of identifying additional tethers which may be comprised, together with antigenic sequences, in conjugate peptides.

La présente invention porte sur (i) des peptides conjugués conçus de façon à se lier de manière non covalente aux protéines du stress; (ii) des compositions comprenant ces peptides conjugués, éventuellement liés aux protéines du stress; et (iii) des procédés d'utilisation de ces composés visant à induire une réponse immune chez un sujet nécessitant ce type de traitement. Cette invention se base, au moins en partie, sur la découverte de molécules de liaison qui peuvent être utilisées pour lier de manière non covalente des peptides antigéniques à des protéines du stress. La présente invention porte également sur des procédés d'identification de liaisons supplémentaires qui peuvent être incluses, avec les séquences antigéniques, dans les peptides conjugués.

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