A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2441442
The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS- active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
La présente invention concerne des composés contenant un conjugué d'amidon hydroxyalkylé (HAS) et d'un agent actif, l'amidon hydroxyalkylé étant lié par covalence à l'agent actif, soit directement soit par l'intermédiaire d'un lieur. L'invention concerne également des procédés de fabrication d'un conjugué covalent d'amidon hydroxyalkylé et d'agent actif consistant à faire réagir de l'amidon hydroxyalkylé et un agent actif dans un milieu de réaction. Lesdits procédés sont caractérisés en ce que le milieu de réaction est de l'eau ou un mélange d'eau et de solvant organique contenant au moins 10 % en poids d'eau.
Eichner Wolfram
Frie Sven
Jungheinrich Cornelius
Lutterbeck Katharina
Scharpf Roland
Fresenius Kabi Deutschland Gmbh
Ridout & Maybee Llp
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