Conjugated factor viii molecules

Details Conjugated factor viii molecules Conjugated factor viii molecules

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2715465

The present invention relates to B-domain truncated Factor VIII molecules with a modified circulatory half life, said molecule being covalently conjugated with a hydrophilic polymer. The invention furthermore relates to methods for obtaining such molecules as well as use of such molecules.

La présente invention concerne des molécules de facteur VIII tronquées au niveau du domaine B, dont la demi-vie circulatoire est modifiée, ladite molécule étant conjuguée de façon covalente avec un polymère hydrophile. L'invention concerne en outre des procédés pour obtenir de telles molécules ainsi que lutilisation de telles molécules.

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