Conjugated ketone compounds and their production and use

Details Conjugated ketone compounds and their production and use Conjugated ketone compounds and their production and use

C - Chemistry, Metallurgy

07

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260/578, 260/293

C07D 295/10 (2006.01) C07C 29/42 (2006.01) C07D 209/44 (2006.01) C07D 211/52 (2006.01) C07D 295/108 (2006.01) C07D 307/52 (2006.01) C07D 317/58 (2006.01) C07D 333/22 (2006.01)

Patent

CA 1151164

Abstract of the Disclosure: Conjugated ketone compounds of the formula: Image wherein Ar is naphthyl, furyl, thienyl, or phenyl op- tionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, trifluoromethyl and methyl- enedioxy, R1 is C1-C6 alkyl, C3-C5 alkenyl, C3-C6 cyclo- alkyl, C7-C8 aralkyl or adamantyl, R2 is C1-C6 alkyl, C3-C5 alkenyl or C3-C6 cycloalkyl, or when R1 and R2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group selected from pyrro- lidino, piperidino, morpholino, 3-azabicyclo[3,2,2]non- anyl and isoindolinyl groups, A is straight or branched C1-C3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans- butenyl]-morpholine and n-[4-(p-methoxyphenyl)-4-oxo- 2-trans-butenyl]-piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.

319260

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