Conjugated linolenic acids and methods of preparation and...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 57/12 (2006.01) A61K 31/202 (2006.01) C07C 13/21 (2006.01) C11C 3/14 (2006.01)

Patent

CA 2534670

This invention relates to a new conjugated linoleic acids, a process for preparation thereof and method of use. Thus this invention is concerned with the preparation and purification of conjugated linoleic acids from materials rich in alpha or gamma linoleic acids. The reaction produces a mixture containing a 1:1 ratio of 9Z, 11E, 15Z-octadecatrienoic acid and 9Z, 13E, 15Z- octadecatrieonic acid. The mixture can be purified up to 90 % by liquid chromatography, crystallization or urea crystallization. The mixture of 1:1 9Z, 11E, 15Z-octadecatrienoic acid and 9Z, 13E, 15E, 15Z-octadecatrienoic acid have anticancerous activities.

L'invention concerne des nouveaux acides linoléniques conjugués, un procédé de préparation de ceux-ci et un procédé d'utilisation de ceux-ci. L'invention concerne également la préparation et la purification d'acides linoléniques conjugués à partir de matériaux riches en acides alpha-linoléniques et en acides gamma-linoléniques. La réaction produit un mélange contenant un rapport de 1:1 d'acide 9Z, 11E, 15Z-octadécatriénoïque et d'acide 9Z, 13E, 15Z-octadécatriénoïque. Ce mélange peut être purifié jusqu'à 90 % par chromatographie en phase liquide, par cristallisation ou par cristallisation de l'urée. Ledit mélange contenant un rapport de 1:1 d'acide 9Z, 11E, 15Z-octadécatriénoïque et d'acide 9Z, 13E, 15Z-octadécatriénoïque présente des activités anticancéreuses.

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