Conjugated peptides, immunological reagent containing same...

Details Conjugated peptides, immunological reagent containing same... Conjugated peptides, immunological reagent containing same...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) C07K 14/16 (2006.01) C07K 14/74 (2006.01) C07K 16/10 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2262427

A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of .beta.-2 microglobulin to a modified HGP-30 antigenic peptide fragment of p17 gag peptide, such as, for example (I). The heteroconjugate is effective in eliciting a TH1 directed immune response and provides a vaccine composition for treating or preventing AIDS.

On a formé un hétéroconjugué en liant un ligand de fixation d'un lymphocyte T (TCBL), tel qu'un peptide J d'une microglobuline .beta.-2, à un fragment peptidique antigénique HGP-30 modifié du peptide p17 gag, comme par exemple (I). Cet hétéroconjugué est efficace pour déclencher une réponse immune dirigée de TH1 et constitue une composition vaccinale destinée à traiter ou prévenir le SIDA.

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