Conjugated small molecules

Details Conjugated small molecules Conjugated small molecules

A - Human Necessities

61

K

A61K 47/48 (2006.01) G01N 33/50 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2551495

Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residus of 6-aminohexanoic acid and optionally 7-10 residus of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnoistic, separation, and therapeutic applications.

L'invention concerne des composés de liaison et des conjugués les comportant. Dans un mode de réalisation, les composés de liaison comprennent deux ou trois groupes d'acide 6-aminohexanoïque et éventuellement sept à dix groupes de polyéthylèneglycol (PEG). Ces composés de liaison servent à former des conjugués à un ou plusieurs composants, destinés à des applications biopharmaceutiques et bioanalytiques, les composés utiles en biopharmacie étant notamment des inhibiteurs de kinase. Les conjugués de la présente invention peuvent servir dans toute une série d'applications relatives au diagnostic, à la séparation et à la thérapeutique.

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