Conjugated vi saccharides

Details Conjugated vi saccharides Conjugated vi saccharides

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2727565

Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.

Deux conjugués Vi ont été préparés par une synthèse induite par les carbodiimides, utilisant la CRM197 dérivatisée de dihydrazide d'acide adipique (un variant non toxique de la toxine de diphtérie) et le toxoïde du tétanos, comme protéines-supports.

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