Conjugates and compositions for cellular delivery

Details Conjugates and compositions for cellular delivery Conjugates and compositions for cellular delivery

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/519 (2006.01) A61K 31/708 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 475/00 (2006.01) C07D 475/04 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C07K 17/02 (2006.01) C12P 17/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) C12N 11/02 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2447161

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HAS) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.

Cette invention porte sur des conjugués, des liants dégradables, des compositions, sur des procédés de synthèse et sur leurs applications. Ces compositions comprennent des conjugués de composés biologiquement actifs dérivés de folate, galactose, galactosamine, N-acétyle galactosamine, PEG, phospholipides, peptides et d'une sérum-albumine humaine comprenant des anticorps, des agents antiviraux, des agents chimiothérapeutiques, des peptides, des protéines, des hormones, des nucléosides, des nucléotides, des non-nucléosides et des acides nucléiques comprenant des acides nucléiques enzymatiques, des DNAzymes, des allozymes, des antisens, dsRNA, siRNA, des oligonucléotides triplex, 2,5-A chimères, des leurres et des aptamères.

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