Conjugates between a peptides and a nucleic acid analog,...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/7125 (2006.01) A61K 47/48 (2006.01) A61L 2/00 (2006.01) A61P 31/04 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388991

The present invention concerns novel drugs for use in combating infectious micro-organisms, in particular bacteria. More particularly the invention concerns peptide nucleic acid (PNA) sequences, which are modified by conjugating cationic peptides to the PNA in order to obtain novel PNA molecules with enhanced anti-infective properties.

La présente invention porte sur de nouveaux médicaments destinés à être utilisés pour combattre les micro-organismes infectieux, notamment les bactéries. L'invention porte précisément sur des séquences d'acide nucléique peptidique (ANP) qui sont modifiées en conjuguant des peptides cationiques à l'ANP afin d'obtenir de nouvelles molécules d'ANP dotées de meilleures propriétés anti-infectieuses.

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