Conjugates comprised of polymer and hiv gp41-derived...

Details Conjugates comprised of polymer and hiv gp41-derived... Conjugates comprised of polymer and hiv gp41-derived...

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2497767

Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.

La présente invention concerne des conjugués comprenant un polymère auquel sont liées au moins deux molécules d'un peptide de synthèse dérivé de VIH gp41, des procédés pour utiliser ces conjugués afin d'inhiber la transmission du VIH à une cellule cible, par addition d'une quantité efficace pour inhiber une infection de la cellule par le virus, ainsi que des procédés pour produire lesdits conjugués par liaison fonctionnelle de chaque molécule de peptide de synthèse au polymère, via une fonctionnalité réactive.

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