Conjugates for dual imaging and radiochemotherapy:...

C - Chemistry – Metallurgy – 08 – B

Patent

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C08B 37/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 35/00 (2006.01) C07B 59/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2593256

Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1-Y-X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

L'invention concerne des compositions et procédés destinés à l'imagerie duelle et à la chimiothérapie et la radiothérapie duelles. L'invention concerne plus précisément des composés contenant la structure X1-Y-X2 où Y comporte au moins deux résidus de carbohydrate reliés par covalence, X1 et X2 représentent des fractions diagnostiques ou thérapeutiques liées par covalence à Y sous réserve que si Y ne contient pas de résidu de glucosamine, X1 et X2 représentent des fractions diagnostiques. La présente invention concerne également des procédés de synthèse de ces composés, l'application de tels composés pour l'imagerie duelle et le traitement de maladies hyperprolifératives, et des trousses de préparation d'un composé thérapeutique ou diagnostique identifié par un marqueur radioactif.

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