Conjugates for the treatment of mesothelioma

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2723823

The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.

La présente invention concerne des conjugués de cytokines et de peptides de ciblage capables de se lier à un récepteur exprimé sur les vaisseaux irriguant les tumeurs ou sur une composante de matrice extracellulaire associée aux vaisseaux tumoraux, dans le cadre du traitement du mésothéliome malin de la plèvre. Linvention porte en particulier sur des conjugués comprenant la cytokine TNF liée à un peptide contenant le motif NRG. Linvention concerne en outre des compositions pharmaceutiques contenant de tels conjugués et des formulations pharmaceutiques renfermant lesdits conjugués dissous dans des tampons appropriés.

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