Conjugates having a degradable linkage and polymeric...

Details Conjugates having a degradable linkage and polymeric... Conjugates having a degradable linkage and polymeric...

C - Chemistry, Metallurgy

08

G

C08G 65/333 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07D 207/46 (2006.01) C07D 401/12 (2006.01) C07K 14/605 (2006.01) C07K 17/08 (2006.01) C08G 65/334 (2006.01)

Patent

CA 2611823

The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

L'invention concerne des conjugués à liaison dégradable ainsi que des réactifs polymères utilisés dans la préparation des conjugués. Les conjugués ainsi que les réactifs polymères utilisés pour former les conjugués contiennent au moins une fraction aromatique contenant un atome d'hydrogène ionisable et/ou une fraction d'espaceur et/ou un polymère hydrosoluble. Par ailleurs, l'invention concerne des procédés de préparation des réactifs polymères et conjugués, ainsi que des procédés d'administration des conjugués et compositions.

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