C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 41/00 (2006.01) A61K 51/06 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2194558
This invention relates to chemically modified oligonucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case, the oligonucleotides are modified in a way that prevents or at least significantly inhibits the degradation by naturally occurring nucleases. The oligonucleotide radical can bond specifically and with high bonding affinity to target structures and can thus produce a specific therapeutic or diagnostic effect by the bound complexing agent or complex.
L'invention concerne des conjugués d'oligonucléotides modifés chimiquement contenant un agent de formation de complexes ou un complexe lié par un consituant de liaison aux oligonucléotides. Dans ce cas, les oligonucléotides sont modifiés d'une manière empêchant ou au moins inhibant sensiblement la dégradation par des nucléases naturelles. Le radical oligonucléotidique peut se lier spécifiquement, avec une haute affinité de liaison, à des structures cibles, il peut par conséquent produire un effet thérapeutique ou diagnostique spécifique par l'agent de formation de complexes ou le complexe lié.
Dinkelborg Ludger
Gold Larry
Hilger Christoph-Stephan
Niedballa Ulrich
Pieken Wolfgang
Bayer Schering Pharma Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nexstar Pharmaceuticals Inc.
Schering Aktiengesellschaft
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