Conjugates of a cholinesterase moiety and a polymer

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01)

Patent

CA 2723821

Conjugates of a cholinesterase moiety and one or more nonpeptidic, water soluble polymers are provided. Typically, the nonpeptidic, water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.

La présente invention concerne des conjugués d'un groupe fonctionnel cholinestérase et d'un ou plusieurs polymères non peptidiques solubles dans l'eau. Typiquement, le polymère non peptidique soluble dans l'eau est le polyéthylène glycol ou un dérivé de ce composé. L'invention concerne également, entre autres, des compositions comprenant les conjugués, des procédés de fabrication des conjugués et des procédés d'administration des compositions à un patient.

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