Conjugates of a g-csf moiety and a polymer

Details Conjugates of a g-csf moiety and a polymer Conjugates of a g-csf moiety and a polymer

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/535 (2006.01)

Patent

CA 2617064

Conjugates of a G-CSF moiety and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions comprising conjugates to a patient.

L'invention concerne des conjugués d'un groupe fonctionnel G-CSF et d'un ou plusieurs polymères solubles dans l'eau non peptidiques. De manière générale, le polymère soluble dans l'eau non peptidique consiste en du polyéthylène glycol ou un dérivé de celui-ci. L'invention concerne également, entre autres, des compositions contenant des conjugués, des procédés de préparation de ces conjugués, et des procédés d'administration de compositions contenant ces conjugués à un patient.

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